• Featured Product
  • KD/KO Validated

Pentraxin 3 Polyclonal antibody

Pentraxin 3 Polyclonal Antibody for IF, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 13797-1-AP

Synonyms

Pentaxin related protein PTX3, Pentraxin 3, Pentraxin related protein PTX3, PTX3, TNF alpha induced protein 5, TNFAIP5, TSG 14, TSG14



Tested Applications

Positive WB detected inHUVEC cells, HeLa cells, Jurkat cells, HepG2 cells
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Product Information

13797-1-AP targets Pentraxin 3 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, bovine
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Pentraxin 3 fusion protein Ag4624 相同性解析による交差性が予測される生物種
Full Name pentraxin-related gene, rapidly induced by IL-1 beta
Calculated molecular weight 381 aa, 42 kDa
Observed molecular weight 40-45 kDa
GenBank accession numberBC039733
Gene symbol PTX3
Gene ID (NCBI) 5806
RRIDAB_2165302
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Pentraxin 3 (PTX3), also known as TNF-inducible gene 14 protein (TSG-14), is a member of the pentraxin superfamily which consists of evolutionarily conserved proteins characterized by a structural motif99, the pentraxin domain (PMID: 15771574). Pentraxin 3 can be produced by a variety of cell types including endothelial cells, smooth muscle cells, adipocytes, fibroblasts, mononuclear phagocytes, and dendritic cells, and its expression is induced by primary inflammatory signals, such as IL-1, TNF, and microbial moieties (PMID: 15771574). Pentraxin 3 is an acute phase glycoprotein that plays a role in the regulation of innate resistance to pathogens, inflammation, tissue remodeling and repair, female fertility and cancer (PMID: 29412047). Pentraxin 3 is a biomarker for cardiovascular disease (PMID: 22347626). Increased plasma Pentraxin 3 levels have been found in patients with cardiovascular disorders (PMID: 22347626; 31057548). In WB, there're two major bands, an upper signal at 80-86 kDa and a lower signal at 42 kDa, representing Pentraxin 3 dimers and monomers, respectively (PMID: 18223257).

Protocols

Product Specific Protocols
WB protocol for Pentraxin 3 antibody 13797-1-APDownload protocol
IF protocol for Pentraxin 3 antibody 13797-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Sci Adv

Urchin-like ceria nanoparticles for enhanced gene therapy of osteoarthritis

Authors - Haoyi Chen
humanWB

Nat Commun

SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.

Authors - Peiyuan Zhang
humanWB

Front Cell Dev Biol

Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy.

Authors - Zeyu Wang
human,mouseWB

Ecotoxicol Environ Saf

PTX3 alleviates hard metal-induced acute lung injury through potentiating efferocytosis.

Authors - Weiwen Yan
humanWB

J Proteomics

Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Authors - Sun-Xia Chen
humanWB,IHC

CNS Neurosci Ther

PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma.

Authors - Hao Zhang
  • KD Validated