PICK1 Monoclonal antibody

PICK1 Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Mouse, Rat, Pig

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

2E11A4

Cat no : 67099-1-Ig

Synonyms

PICK, PICK1, PRKCA binding protein, PRKCABP



Tested Applications

Positive WB detected inHeLa cells, LNCaP cells, MCF-7 cells, pig brain tissue, rat brain tissue, mouse brain tissue
Planning an IF experiment? We recommend our CoraLite®488 conjugated versions of this antibody.

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
Sample-dependent, check data in validation data gallery

Product Information

67099-1-Ig targets PICK1 in WB,ELISA applications and shows reactivity with Human, Mouse, Rat, Pig samples.

Tested Reactivity Human, Mouse, Rat, Pig
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen PICK1 fusion protein Ag28609
Full Name protein interacting with PRKCA 1
Calculated molecular weight 47 kDa
Observed molecular weight 50 kDa
GenBank accession numberBC017561
Gene symbol PICK1
Gene ID (NCBI) 9463
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

Protein interacting with C kinase 1 (PICK1) was first cloned as a PKC-binding partner through yeast two hybrid system. PICK1 acts as a critical regulator of membrane receptors’ subcellular trafficking to modulate neural processes such as learning and memory, and is widely expressed in brain, testis, heart, lung, liver, kidney and muscle. It probably binds to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence, for instance, PICK1 is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. PICK1 expression on D-serine release and glutamate transport in astrocytes suggests a potential implication of PICK1 in the progression of amyotrophic lateral sclerosis (ALS). PICK1 may also participate in breast cancer development through inhibition of TGF-β signaling.

Protocols

Product Specific Protocols
WB protocol for PICK1 antibody 67099-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols