Validation Data Gallery
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Tested Applications
| Positive WB detected in | A431 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 12 publications below |
| IHC | See 3 publications below |
| IF | See 1 publications below |
| CoIP | See 1 publications below |
Product Information
19698-1-AP targets LAMC2 in WB, IHC, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | laminin, gamma 2 |
| Calculated molecular weight | 131 kDa |
| Observed molecular weight | 140 kDa |
| GenBank accession number | NM_005562 |
| Gene Symbol | LAMC2 |
| Gene ID (NCBI) | 3918 |
| RRID | AB_10644139 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q13753 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
LAMC2, also named as LAMB2T and LAMNB2, is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. LAMC2 binds to cells via a high affinity receptor. Laminin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for LAMC2 antibody 19698-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Cancer Res A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer | ||
Sci Transl Med Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation | ||
J Immunother Cancer Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization. | ||
J Transl Med Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction | ||
Int J Mol Med The Notch pathway mediates the angiotensin II-induced synthesis of extracellular matrix components in podocytes. | ||
Phytother Res Dioscin Suppresses Ovarian and Gastric Tumor Progression by Inhibiting ALDH1A3-Mediated Retinoic Acid Metabolism and Cancer Stemness. |