Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 3 publications below |
| WB | See 5 publications below |
Product Information
51001-2-AP targets ICMT in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | isoprenylcysteine carboxyl methyltransferase |
| Calculated molecular weight | 284 aa, 32 kDa |
| Observed molecular weight | 30-34 kDa |
| GenBank accession number | BC028168 |
| Gene Symbol | ICMT |
| Gene ID (NCBI) | 23463 |
| RRID | AB_2122574 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O60725 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
Publications
| Species | Application | Title |
|---|---|---|
J Clin Invest Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.
| ||
J Cell Biol Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
| ||
Oncotarget Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. | ||
Life Sci Alliance NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.
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J Biol Chem Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor. |