|cell culture supernatants||101%||90%-116%|
SERPINA1 is the archetypal member of the Serpin superfamily of the serine protease inhibitors. It is an acute phase glycoprotein mainly (by 80%) synthesized in human liver and is a major blood protein after albumin and the Immunoglobulins. SERPINA1 plays a key antiinflammatory role to protect tissues against proteolytic digestion by elastase secreted by neutrophils. In patients with carcinomas, it was reported that SERPINA1 promotes invasive and metastatic capacity in lung cancer, gastric cancer, and colorectal carcinomas.Several studies demonstrated that higher levels of SERPINA1 correlate with more advanced cancer stages. Defects in this gene can cause emphysema or liver disease.