容量: 1 Kit (96 assays)
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| Sample Type | Average | Range |
|---|---|---|
| Human plasma | 107% | 98%-119% |
| Cell lysates | 109% | 94%-118% |
| Sample | n | mean (pg/mL) | SD | CV% |
|---|---|---|---|---|
| 1 | 20 | 1,439.3 | 73.7 | 5.1 |
| 2 | 20 | 304.1 | 18.3 | 6.0 |
| 3 | 20 | 75.5 | 3.3 | 4.3 |
| Sample | n | mean (pg/mL) | SD | CV% |
|---|---|---|---|---|
| 1 | 24 | 1,463.9 | 76.7 | 5.2 |
| 2 | 24 | 313.0 | 17.4 | 5.6 |
| 3 | 24 | 85.1 | 4.1 | 4.9 |
CYB5R3, also named as DIA1 and B5R, belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in red blood cells. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms. The ELISA kit is suitable for testing serum, plasma, and cell lysates.
