FOXP2 Polyclonal antibody
FOXP2 Polyclonal Antibody for IP, WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IP, IHC, IF, CoIP, ELISA
Conjugate
Unconjugated
Cat no : 20529-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | HEK-293 cells, mouse brain tissue, mouse spleen tissue |
| Positive IP detected in | mouse spleen tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB |
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 2 publications below |
| IHC | See 1 publications below |
| IF | See 1 publications below |
| CoIP | See 1 publications below |
Product Information
The immunogen of 20529-1-AP is FOXP2 Fusion Protein expressed in E. coli.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | FOXP2 fusion protein Ag14391 |
| Full Name | forkhead box P2 |
| Calculated molecular weight | 80 kDa |
| Observed molecular weight | 70-80 kDa |
| GenBank accession number | BC018016 |
| Gene symbol | FOXP2 |
| Gene ID (NCBI) | 93986 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
FOXP2, also named as CAGH44 or TNRC10, is a 715 amino acid protein, which is a transcription factor containing a polyglutamine tract, a zinc-finger motif, and a forkheadDNA-binding domain. The role of FOXP2 in this neurodevelopmental disorder suggests that mutations in FOXP2 could cause other neuropsychiatric disorders. FOXP2 is the first gene linked to human speech and has been the target of positive selection during recent primate evolution. FOXP2 exists several isoform with the range of molecular weight 70-80 kDa and 40-50 kDa (PMID: 15056696; PMID: 29360038).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for FOXP2 antibody 20529-1-AP | Download protocol |
| IP protocol for FOXP2 antibody 20529-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
J Cancer Low expression of FOXP2 predicts poor survival and targets caspase-1 to inhibit cell pyroptosis in colorectal cancer.
| ||
Mol Ther Nucleic Acids circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. |
