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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

CoraLite® Plus 488-conjugated FAH Monoclonal antibody

FAH Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig, rat, mouse

Applications

IF

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

2F8E11

Cat no : CL488-67986

Synonyms

Beta diketonase, FAA, FAH, Fumarylacetoacetase, Fumarylacetoacetate hydrolase

Validation Data Gallery

Applications:
  • IF Staining of HepG2 using CL488-67986

    IF Staining of HepG2 using CL488-67986

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using CoraLite® Plus 488 FAH antibody (CL488-67986, Clone: 2F8E11 ) at dilution of 1:200.

Tested Applications

Positive IF detected inHepG2 cells
For other applications, we recommend the unconjugated version of this antibody, 67986-1-Ig

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

CL488-67986 targets FAH in IF applications and shows reactivity with Human, pig, rat, mouse samples.

Tested Reactivity Human, pig, rat, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen FAH fusion protein Ag6704 相同性解析による交差性が予測される生物種
Full Name fumarylacetoacetate hydrolase (fumarylacetoacetase)
Calculated molecular weight 46 kDa
Observed molecular weight 40-45 kDa
GenBank accession numberBC002527
Gene symbol FAH
Gene ID (NCBI) 2184
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Purification Method Protein G purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

FAH is also named as FAA(fumarylacetoacetase), the last enzyme in tyrosine degradation, functionally important in the liver and kidney(PMID:8473520). FAH is a metabolic enzyme catalyzing the last step of tyrosine and phenylalanine catabolism: the hydrolysis of fumarylacetoacetate into acetoacetate and fumarate. In humans, deficiency of this activity is associated with the metabolic disease hereditary tyrosinaemia type I, which is also known as hepatorenal tyrosinaemia(PMID:17768357).

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 FAH antibody CL488-67986Download protocol
Standard Protocols
Click here to view our Standard Protocols