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Endoglin/CD105 抗体 1 文献

Rabbit Polyclonal| カタログ番号: 28117-1-AP

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適用アプリケーション

アプリケーション:
WB, IHC,ELISA
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Images See all

Endoglin/CD105 Antibody WB HUVEC cells 28117-1-AP

HUVEC cells were subjected to SDS PAGE followed by western blot with 28117-1-AP (Endoglin/CD105 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Endoglin/CD105 Antibody IHC human liver cancer tissue 28117-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 28117-1-AP (Endoglin/CD105 antibody) at dilution of 1:600 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Endoglin/CD105 Antibody IHC human liver cancer tissue 28117-1-AP

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 28117-1-AP (Endoglin/CD105 antibody) at dilution of 1:600 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

種特異性:
Human
WB ポジティブ:
HUVEC cells
IHC ポジティブ:
human liver cancer tissue, human renal cell carcinoma tissue, human breast cancer tissue, human placenta tissue
推奨希釈倍率:
WB : 1:500-1:1000
IHC : 1:300-1:1200

Protocols

Product-specific protocols

Standard Protocols

製品情報

由来:
Rabbit
精製方法:
Antigen affinity purification
アイソタイプ:
IgG
バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

ターゲット情報

免疫原:
Endoglin/CD105 fusion protein Ag27822
正式名:
endoglin
計算分子量:
71 kDa
検出分子量:
95 kDa
GenBank accession number:
BC014271
Gene ID (NCBI):
2022
遺伝子シンボル:
ENG
別名:
CD105, END, Endoglin, ENG, FLJ41744, HHT1, ORW, ORW1

背景説明

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)


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