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Endoglin/CD105 抗体 11 文献

Rabbit Polyclonal| カタログ番号: 10862-1-AP

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Related Primary Antibodies

適用アプリケーション

アプリケーション:
WB, IP, IHC, IF, ELISA
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Images See all

Endoglin/CD105 Antibody WB human placenta tissue 10862-1-AP

human placenta tissue was subjected to SDS PAGE followed by western blot with 10862-1-AP (Endoglin/CD105 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Endoglin/CD105 Antibody IHC human breast cancer tissue 10862-1-AP

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10862-1-AP (Endoglin/CD105 antibody) at dilution of 1:4000 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Endoglin/CD105 Antibody IHC human breast cancer tissue 10862-1-AP

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 10862-1-AP (Endoglin/CD105 antibody) at dilution of 1:4000 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Endoglin/CD105 Antibody IP mouse lung tissue 10862-1-AP

IP Result of anti-Endoglin/CD105 (IP:10862-1-AP, 3ug; Detection:10862-1-AP 1:300) with mouse lung tissue lysate 4000ug.

種特異性:
human, mouse, Bovine, rat
WB ポジティブ:
human placenta tissue
IP ポジティブ:
mouse lung tissue
IHC ポジティブ:
human breast cancer tissue, human placenta tissue
推奨希釈倍率:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:1000-1:4000

Protocols

Product-specific protocols

Standard Protocols

製品情報

由来:
Rabbit
精製方法:
Antigen affinity purification
アイソタイプ:
IgG
バッファー/保存方法:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

ターゲット情報

免疫原:
Endoglin/CD105 fusion protein Ag1287
正式名:
endoglin
計算分子量:
71 kDa
検出分子量:
75-90 kDa, 170-180 kDa
GenBank accession number:
BC014271
Gene ID (NCBI):
2022
遺伝子シンボル:
ENG
別名:
CD105, END, Endoglin, ENG, HHT1, ORW, ORW1

背景説明

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)


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