|Cell culture supernatants||111%||98%-123%|
IL-28B, also named as IFNL3, is a cytokine distantly related to type I interferons and the IL-10 family. IL-28B, interleukin 28A (IL-28A), and interleukin 29 (IL-29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL-10RB) and interleukin 28 receptor, alpha (IL-28RA). IL-28B was identified as a key regulator of B- and T-cell vaccine responses against influenza.