• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-17 (IL-17A) protein

Activity

0.24-1.2 ng/mL EC50

Specific Activity

2.33 x 107 IU/mg

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1113

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, IL-17A, interleukin 17A



Technical Specifications

GeneID 3605
Species Human
Expression HEK293
Activity 0.24-1.2 ng/mL EC50
Specific Activity2.33 x 107 IU/mg
Purity >95%
Endotoxin<1 EU/µg
Accession NumberQ16552
Molecular Mass 29 to 34 kDa, homodimer, glycosylated
Formulation 10 mM Tris-HCl pH 7.4+ 250 mM NaCl, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

IL-17 (IL-17A) is a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464).

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, IL-17A, interleukin 17A

Publications

SpeciesTitle
human

Oncoimmunology

IL-17 induces antitumor immunity by promoting beneficial neutrophil recruitment and activation in esophageal squamous cell carcinoma.

Authors - Chang-Long Chen
human

J Invest Dermatol

Chrna5 is overexpressed in psoriasis patients and promotes psoriasis-like inflammation in mouse models.

Authors - Jing Wang
human

Arthritis Rheumatol

Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes.

Authors - YukoToyoda
mouse

J Clin Periodontol

Interleukin-17 alleviates erastin-induced alveolar bone loss by suppressing ferroptosis via interaction between NRF2 and p-STAT3

Authors - Jiaqi Bao
human

Front Immunol

Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis.

Authors - Xinpeng Zhou
human

PLoS One

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.

Authors - KwesiTeye